Study of neutrophil-lymphocyte ratio (NLR) in recent onset type 2 diabetes mellitus

Introduction: The prevalence of type 2 diabetes mellitus (T2DM) is increasing steadily, assuming an epidemic proportion throughout the world. Most this increased burden will come from developing countries. Studies show role inflammation in pathophysiology diabetes. Estimation neutrophil-lymphocyte ratio (NLR) could be a simple, inexpensive marker to stratify at-risk patients. This study aimed estimate NLR and CRP levels as measure systemic diabetics compared healthy controls. We also investigated if was lower with good glycemic control. Methods: A cross-sectional comparative study, conducted tertiary hospital on 60 patients T2DM 69 controls after voluntary informed consent. Anthropometric parameters, fasting plasma glucose, Lipid profile, CBC, CRP, HbA1c were measured for all participants. Results: diabetic group showed significantly higher waist circumference(p=0.007) mean TG (p=0.003), VLDL-c (p=0.001), LDL-c (p=0.010), TG/HDL-c (p=0.00001), MPV (p=0.002), (p=0.006), (p=0.004) values HDL-c (p=0.039) control group. No significant difference seen BMI, Waist -Hip ratio, total cholesterol, cholesterol/HDL-c between two groups. Among diabetics, only (p=0.018) (p=0.049) differed control.Conclusion: Diabetics had inflammatory markers (NLR, CRP) Dyslipidemia (high TG, low high TG/HDL-c) circumference diabetics. fair glycemia (HbA1c < 7%) did not demonstrate indicating that meticulous may ameliorate chronic until dyslipidemia corrected.Â